R&D

TNH BIO
ACTIVE EGF, FGF


01

Overcome the limits of normal EGF

T-EGF has fixed the problems of conventional EGF 

that put limits on the function. 

T-EGF completely implements 

the characteristics of human EGF, 

which forms three disulfide bonds 

in Cys6-Cys20, Cys14-Cys31, Cys33-Cys42, 

constitutes a repeater binding site 

in the 20-31 sequence part, 

and forms an EGF-EGFR complex from Leu15. 


Through this, 

you can observe powerful epidermal regeneration 

that has not been seen before.


02

Idenctical sequence and structure
with Human EGF

T-EGF functions in human body most effectively 

because it forms the same perfect structure as human EGF. 

T-EGF induces differentiation and proliferation of cells in vivo using the user's own signaling mechanism, 

promoting epidermis regeneration and rounding.


03

Mass production technology
of protein with microorgansims

T-EGF is produced through technology that mass-produces recombinant proteins using the gene expression system of microorganisms. 


TNH BIO has implemented enhanced safety 

by minimizing the impact of Lipolysaccharide (LPS) acting 

as Endotoxin by producing optimal vectors. 


The culture environment conditions were set the same 

as the environment when human EGF was created 

and folded to prevent the formation of an inclusion body. 


This produces purer EGF during the purification process. 

In addition, more than 90% of the total secreted proteins are Perfect Structure-EGF, and they are stable and optimized 

for high-rate production. 


The EGF implemented in this way was commercialized by maintaining liquid stabilization at room temperature.


04

The first KDFS certified function
on Wrinkle improvement by EGF

T-EGF is the first ingredient in Korea to be approved 

for the EGF wrinkle improvement functional individual notification by the Ministry of Food and Drug Safety. 


T-EGF maintains the same activity as human EGF 

with a patented technology for room temperature liquid stabilization (patent number: 10-2017-0181340). 


In addition, T-EGF increases the expression of 

Type I collagen by about 2.5 times, helping to improve wrinkles on the skin


TNH BIO's
Pipelines

TNHBIO has become a leading company 

in the field of skin regeneration and is healthy for mankind.
We will move toward a global bio company 

that provides beauty.

PIPELINES
(On R&D)